Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trinitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 11/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | TTR | P02766 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trinitrophenol SCHEMBL2482834 | 0.98 | GPR35 (0.73) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL8744 | 0.98 | GPR35 (0.79) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL253750 | 0.98 | GPR35 (0.79) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL1503376 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL9140811 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL2197458 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL2260890 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL2218625 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL18691159 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL11746249 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102947655-B | Self cooling container and cooling device | CARLSBERG BREWERIES A/S (DK) | 2015-11-25 | — | — | CN | disclosed |
| CN-102308164-B | A system and method for providing a self cooling container | CARLSBERG BREWERIES AS | 2014-11-05 | — | — | CN | disclosed |
| CN-102308163-B | A self cooling container and a cooling device | CARLSBERG BREWERIES AS | 2014-11-05 | — | — | CN | disclosed |
| EP-2583039-A2 | A SELF COOLING CONTAINER AND A COOLING DEVICE | Carlsberg Breweries A/S (DK) | 2013-04-24 | — | — | EP | disclosed |
| CN-102947655-A | A self cooling container and a cooling device | CARLSBERG BREWERIES AS | 2013-02-27 | — | — | CN | disclosed |
| CN-102308164-A | A system and method for providing a self cooling container | CARLSBERG BREWERIES AS | 2012-01-04 | — | — | CN | disclosed |
| CN-102308163-A | A self cooling container and a cooling device | CARLSBERG BREWERIES AS | 2012-01-04 | — | — | CN | disclosed |
| WO-2011157735-A2 | A SELF COOLING CONTAINER AND A COOLING DEVICE | CARLSBERG BREWERIES A/S (DK) | 2011-12-22 | — | — | WO | disclosed |
| US-6511603-B1 | Crown ether, 4,4'(5')(C4- C8-alkylcyclohexano)-18-Crown-6, dispersed onto an inert, porous support; free-flowing particles free of diluent; | ARCH DEVELOPMENT CORP. | 2003-01-28 | — | — | US | disclosed |
| EP-0525100-B1 | METHOD FOR LIQUID CHROMATOGRAPHIC EXTRACTION OF STRONTIUM FROM ACID SOLUTIONS | ARCH DEV CORP THE UNIVERSITY O (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5346618-A | Liquid chromatographic extraction medium | ARCH DEVELOPMENT CORPORATION (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0525100-A4 | METHOD FOR LIQUID CHROMATOGRAPHIC EXTRACTION OF STRONTIUM FROM ACID SOLUTIONS | — | 1993-07-28 | — | — | EP | disclosed |
| EP-0525100-A1 | METHOD FOR LIQUID CHROMATOGRAPHIC EXTRACTION OF STRONTIUM FROM ACID SOLUTIONS. | ARCH DEV CORP THE UNIVERSITY O (US) | 1993-02-03 | — | — | EP | disclosed |
| US-5110474-A | Monitoring nuclear waste pollution | ARCH DEVELOPMENT CORPORATION (US) | 1992-05-05 | — | — | US | disclosed |
| WO-1991015280-A1 | METHOD FOR LIQUID CHROMATOGRAPHIC EXTRACTION OF STRONTIUM FROM ACID SOLUTIONS | ARCH DEVELOPMENT CORPORATION (US) | 1991-10-17 | — | — | WO | disclosed |