SCHEMBL1692873

SCHEMBL1692873

COC(=O)C1(N)CCN(C(=O)OCC(C)C)CC1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.44
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
KIT P10721 1/20 0.39
JAK2 O60674 4/20 0.38
JAK1 P23458 4/20 0.38
RAB9A P51151 1/20 0.38
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
OPRM1 P35372 1/20 0.34
OPRK1 P41145 1/20 0.34
HSD11B1 P28845 1/20 0.34
RORC P51449 1/20 0.34
HRH2 P25021 1/20 0.33
HRH1 P35367 1/20 0.33
USP2 O75604 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3663186 0.81 CYP2D6 (0.42) CYP2D6CYP1A2CYP2C9KITJAK2
SCHEMBL28877805 0.81 USP2 (0.47) CYP2D6CYP1A2CYP2C9ALDH1A1MEN1
SCHEMBL17144637 0.78 LMNA (0.52) CYP2D6ALDH1A1KDM4EOPRK1HRH2
SCHEMBL26705610 0.76 RORC (0.39) CYP2D6CYP1A2CYP2C9KITJAK2
SCHEMBL9657187 0.74 SMN1; SMN2 (0.58) CYP2D6CYP2C9RAB9AALDH1A1KDM4E
SCHEMBL2786348 0.74 CYP3A4 (0.34) CYP2D6CYP1A2CYP2C9ALDH1A1MEN1
SCHEMBL1692872 0.74 USP2 (0.47) ALDH1A1HPGDUSP2
SCHEMBL1127578 0.73 GAA (0.39) CYP2D6CYP1A2CYP2C9KITJAK2
SCHEMBL5407237 0.73 MEN1 (0.52) KITRAB9AALDH1A1MEN1HPGD
SCHEMBL12233216 0.73 RAB9A (0.51) KITRAB9AALDH1A1MEN1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011149841-A1 SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-α MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2011-12-01 WO disclosed