Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 4/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.42 |
| ▸ | FAP | Q12884 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16938900 | 0.90 | FAP (0.37) | MMP3ADAM17FAPHDAC1HDAC4 | |
| SCHEMBL16938903 | 0.88 | HDAC1 (0.38) | MMP3ADAM17FAPHDAC1HDAC4 | |
| SCHEMBL16938901 | 0.83 | HDAC1 (0.36) | HDAC1HDAC4HDAC6HDAC3PSMB8 | |
| SCHEMBL16938909 | 0.79 | HDAC4 (0.36) | FAPHDAC1HDAC4HDAC6PSMB8 | |
| SCHEMBL16938975 | 0.79 | FAP (0.35) | FAPHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL16938906 | 0.77 | HDAC1 (0.36) | FAPHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL16938953 | 0.74 | GAA (0.33) | FAPHDAC1HDAC4HDAC6 | |
| SCHEMBL16938890 | 0.74 | FAP (0.32) | FAPHDAC1HDAC4HDAC6 | |
| SCHEMBL16938907 | 0.74 | FAP (0.32) | FAPHDAC1HDAC4HDAC6 | |
| SCHEMBL16938908 | 0.71 | TSHR (0.34) | FAPHDAC1HDAC4HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364310-B1 | 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2015-07-29 | — | — | EP | disclosed |