Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.37 |
| ▸ | FAP | Q12884 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16938957 | 0.88 | MMP3 (0.42) | HDAC1HDAC4HDAC6FAPHDAC3 | |
| SCHEMBL16938900 | 0.81 | FAP (0.37) | HDAC1HDAC4HDAC6FAPHDAC3 | |
| SCHEMBL16938909 | 0.76 | HDAC4 (0.36) | HDAC1HDAC4HDAC6FAPDDB1 | |
| SCHEMBL16938975 | 0.76 | FAP (0.35) | HDAC1HDAC4HDAC6FAPHDAC3 | |
| SCHEMBL16938901 | 0.75 | HDAC1 (0.36) | HDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL16938890 | 0.73 | FAP (0.32) | HDAC1HDAC4HDAC6FAPTSHR | |
| SCHEMBL16938907 | 0.73 | FAP (0.32) | HDAC1HDAC4HDAC6FAPTSHR | |
| SCHEMBL16938953 | 0.72 | GAA (0.33) | HDAC1HDAC4HDAC6FAPTSHR | |
| SCHEMBL16938906 | 0.70 | HDAC1 (0.36) | HDAC1HDAC4HDAC6FAPHDAC3 | |
| SCHEMBL16938908 | 0.69 | TSHR (0.34) | HDAC1HDAC4HDAC6FAPHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364310-B1 | 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2015-07-29 | — | — | EP | disclosed |