Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16939362 | 0.80 | TDO2 (0.51) | JAK2PIM1PRKD3GSK3BDYRK1A | |
| SCHEMBL31512553 | 0.80 | MAPT (0.54) | CDK5PIM1PRKD3PDGFRBGSK3B | |
| SCHEMBL4042003 | 0.80 | MAPT (0.54) | CDK5PIM1PRKD3PDGFRBGSK3B | |
| SCHEMBL28212089 | 0.77 | JAK2 (0.59) | JAK2CDK5PIM1PRKD3PDGFRB | |
| SCHEMBL2601265 | 0.76 | JAK2 (0.63) | JAK2CDK5PIM1PRKD3PDGFRB | |
| SCHEMBL13885299 | 0.75 | JAK2 (0.63) | JAK2CDK5PIM1PRKD3PDGFRB | |
| SCHEMBL13885395 | 0.75 | JAK2 (0.61) | JAK2CDK5PIM1PRKD3PDGFRB | |
| SCHEMBL13885309 | 0.75 | JAK2 (0.61) | JAK2CDK5PIM1PRKD3PDGFRB | |
| SCHEMBL5249231 | 0.75 | CDK5 (0.50) | CDK5PIM1PRKD3PDGFRBGSK3B | |
| SCHEMBL4006751 | 0.74 | JAK2 (1.00) | JAK2CDK5PIM1PRKD3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015110092-A1 | 4-SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINE COMPOUND AND USE THEREOF | 江苏柯菲平医药股份有限公司 | 2015-07-30 | — | — | WO | disclosed |