Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 3/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042003 | 0.75 | MAPT (0.54) | CDK5CDK5R1CLK1PIM1PRKD3 | |
| SCHEMBL31512553 | 0.75 | MAPT (0.54) | CDK5CDK5R1CLK1PIM1PRKD3 | |
| SCHEMBL29990617 | 0.75 | TDO2 (0.52) | CDK5CDK5R1CLK1GSK3BDYRK1A | |
| SCHEMBL16939183 | 0.75 | JAK2 (0.58) | CDK5CDK5R1CLK1PIM1PRKD3 | |
| SCHEMBL5247265 | 0.75 | CDK5 (0.55) | CDK5CDK5R1CLK1PIM1PRKD3 | |
| SCHEMBL22510124 | 0.72 | CDK5 (0.56) | CDK5CDK5R1CLK1PIM1GSK3B | |
| SCHEMBL17150733 | 0.72 | CDK5 (0.71) | CDK5CDK5R1CLK1PIM1GSK3B | |
| SCHEMBL2205723 | 0.72 | MEN1 (0.54) | CDK5CDK5R1CLK1PIM1PRKD3 | |
| SCHEMBL7027583 | 0.72 | MAPT (0.54) | CDK5CDK5R1CLK1PIM1PRKD3 | |
| SCHEMBL25034155 | 0.71 | PDGFRB (0.57) | CDK5CDK5R1CLK1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848506-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | Attenuon, LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089298-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | ATTENUON, LLC (US) | 2006-08-24 | — | — | WO | disclosed |