Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | TDO2 | P48775 | 5/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31512553 | 1.00 | MAPT (0.54) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL31469323 | 0.84 | EGFR (0.58) | MAPTSMN1; SMN2MEN1KMT2ATDO2 | |
| SCHEMBL16939183 | 0.80 | JAK2 (0.58) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL6181492 | 0.79 | EGFR (0.72) | PDGFRBPDGFRA | |
| SCHEMBL7027583 | 0.76 | MAPT (0.54) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL13911021 | 0.76 | ADORA2A (0.64) | ALDH1A1LMNASMN1; SMN2ADORA2APIM1 | |
| SCHEMBL3075421 | 0.75 | ADORA2A (0.75) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL5249231 | 0.75 | CDK5 (0.50) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL31469345 | 0.75 | AURKB (0.48) | TDO2 | |
| SCHEMBL38651268 | 0.74 | MAPT (0.59) | MAPTALDH1A1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111087391-A | 4-indole quinazoline compound and preparation method and application thereof | 郑州大学 | 2020-05-01 | — | — | CN | claimed |
| CN-109096254-B | Quinazoline derivative and preparation method and application thereof | 江西师范大学 | 2021-07-06 | — | — | CN | disclosed |
| CN-111087391-A | 4-indole quinazoline compound and preparation method and application thereof | 郑州大学 | 2020-05-01 | — | — | CN | disclosed |
| CN-106496196-A | Or a kind of quinazoline, Pyridopyrimidine be double and pyrimidine derivatives egf inhibitor and preparation method thereof and purposes | 南京雷科星生物技术有限公司 | 2017-03-15 | — | — | CN | disclosed |
| CN-101619042-B | Method for synthesizing aromatic pyrimidine-4(3H)-ketone compounds | UNIV ZHEJIANG TECHNOLOGY | 2011-11-09 | — | — | CN | disclosed |
| CN-101619042-A | Method for synthesizing aromatic pyrimidine-4(3H)-ketone compounds | UNIV ZHEJIANG TECHNOLOGY | 2010-01-06 | — | — | CN | disclosed |
| WO-2009103719-A1 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND USE AND PRODUCTION THEREOF | FREIE UNIVERSITÄT BERLIN (DE) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009103719-A1 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND USE AND PRODUCTION THEREOF | FREIE UNIVERSITÄT BERLIN (DE) | 2009-08-27 | — | — | WO | disclosed |
| EP-1846396-A2 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND THEIR USE | Freie Universität Berlin (DE) | 2007-10-24 | — | — | EP | disclosed |
| EP-1846396-A2 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND THEIR USE | Freie Universität Berlin (DE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006084882-A8 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND THEIR USE | UNIV BERLIN FREIE (DE) | 2007-06-07 | — | — | WO | disclosed |
| WO-2006084882-A3 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND THEIR USE | FREIE UNIVERSTIAET BERLIN (DE) | 2006-12-07 | — | — | WO | disclosed |
| WO-2006084882-A2 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND THEIR USE | FREIE UNIVERSITÄT BERLIN (DE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006084882-A2 | SUBSTITUTED 4-(INDOL-3-YL)QUINAZOLINES AND THEIR USE | FREIE UNIVERSITÄT BERLIN (DE) | 2006-08-17 | — | — | WO | disclosed |