Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 20/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170992 | 0.93 | OPRK1 (0.86) | OPRK1 | |
| SCHEMBL18993305 | 0.83 | OPRK1 (1.00) | OPRK1OPRM1OPRD1 | |
| SCHEMBL16944608 | 0.82 | OPRK1 (1.00) | OPRK1 | |
| SCHEMBL16945045 | 0.81 | OPRK1 (1.00) | OPRK1 | |
| SCHEMBL21170929 | 0.81 | OPRK1 (0.75) | OPRK1OPRM1OPRD1 | |
| SCHEMBL21171251 | 0.81 | OPRK1 (0.72) | OPRK1 | |
| SCHEMBL16945088 | 0.80 | OPRK1 (1.00) | OPRK1 | |
| SCHEMBL21171465 | 0.79 | OPRK1 (0.64) | OPRK1 | |
| SCHEMBL21170987 | 0.79 | OPRK1 (0.64) | OPRK1 | |
| SCHEMBL18994678 | 0.78 | OPRK1 (1.00) | OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2884978-B1 | NOVEL KAPPA OPIOID LIGANDS | SCRIPPS RESEARCH INST (US) | 2019-07-17 | — | — | EP | disclosed |
| US-20180099954-A1 | NOVEL KAPPA OPIOID LIGANDS | SCRIPPS RESEARCH INST (US) | 2018-04-12 | — | — | US | disclosed |
| US-20180099954-A1 | NOVEL KAPPA OPIOID LIGANDS | SCRIPPS RESEARCH INST (US) | 2018-04-12 | — | — | US | disclosed |
| US-9682966-B2 | Kappa opioid ligands | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682966-B2 | Kappa opioid ligands | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-20 | — | — | US | disclosed |
| US-20150210673-A1 | NOVEL KAPPA OPIOID LIGANDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-07-30 | — | — | US | disclosed |
| US-20150210673-A1 | NOVEL KAPPA OPIOID LIGANDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210673-A1 | NOVEL KAPPA OPIOID LIGANDS | OPRK1, OPRD1, OPRL1 | OPRK1 1/4885OPRM1 4/4885OPRD1 2/4885 |
| US-20180099954-A1 | NOVEL KAPPA OPIOID LIGANDS | OPRK1, OPRD1, OPRL1 | OPRK1 1/4885OPRM1 4/4885OPRD1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.