Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28941074 | 0.89 | EGFR (0.51) | EGFRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL27847284 | 0.87 | ALDH1A1 (0.52) | ALDH1A1LMNATDP1MAPK1MAPT | |
| SCHEMBL13400411 | 0.87 | TSHR (0.49) | CYP1A2PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL21824095 | 0.86 | ALDH1A1 (0.60) | CYP1A2ALDH1A1LMNATDP1MAPK1 | |
| SCHEMBL492505 | 0.86 | CYP1A2 (0.64) | CYP1A2ALDH1A1LMNATDP1MAPK1 | |
| SCHEMBL5201986 | 0.86 | LMNA (0.49) | CYP1A2PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL5216573 | 0.85 | PDGFRB (0.57) | EGFRCYP1A2PDGFRBFGFR1PDGFRA | |
| SCHEMBL17675673 | 0.84 | MAPT (0.53) | CYP1A2PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL7226743 | 0.84 | ALDH1A1 (0.50) | CYP1A2PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL5917471 | 0.84 | CYP1A2 (0.44) | CYP1A2PDGFRBFGFR1PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2577309-A1 | TARGETED PROBES OF CELLULAR PHYSIOLOGY | Carnegie Mellon University (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011150079-A1 | TARGETED PROBES OF CELLULAR PHYSIOLOGY | CARNEGIE MELLON UNIVERSITY (US) | 2011-12-01 | — | — | WO | disclosed |