Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695204 | 0.82 | KDM4E (0.35) | KDM4ERAB9AERN1MEN1KMT2A | |
| SCHEMBL24596021 | 0.79 | SMN1; SMN2 (0.47) | KDM4ERAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2719332 | 0.78 | MEN1 (0.44) | KDM4EMEN1KMT2A | |
| SCHEMBL29098600 | 0.72 | MTNR1A (0.43) | KDM4ERAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15228446 | 0.72 | PIM1 (0.39) | ERN1 | |
| SCHEMBL15660706 | 0.71 | ALDH1A1 (0.55) | KDM4ERAB9AERN1MEN1KMT2A | |
| SCHEMBL1694814 | 0.71 | ALDH1A1 (0.46) | KDM4ERAB9AMEN1KMT2AGPR3 | |
| SCHEMBL1695020 | 0.71 | GPR3 (0.41) | KDM4EGPR3CASP3PARP1PDE10A | |
| SCHEMBL24597739 | 0.71 | KDM4E (0.38) | KDM4ERAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1695174 | 0.70 | SMN1; SMN2 (0.50) | KDM4ERAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |