Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460479 | 0.86 | SMN1; SMN2 (0.43) | LMNAALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8425831 | 0.78 | CYP1A2 (0.47) | LMNAALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL145464 | 0.78 | ALDH1A1 (0.48) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL16953866 | 0.78 | GRM5 (0.41) | LMNAALDH1A1MAPTKDM4EHTT | |
| SCHEMBL24312388 | 0.77 | KDM4E (0.38) | LMNAALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16961006 | 0.77 | SMN1; SMN2 (0.38) | LMNAALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16959195 | 0.76 | SCN8A (0.38) | LMNAALDH1A1MAPTSMN1; SMN2SCN4A | |
| SCHEMBL699869 | 0.74 | TDP1 (0.41) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL9760835 | 0.72 | CA1 (0.58) | LMNAALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16952045 | 0.72 | APOBEC3G (0.44) | LMNAALDH1A1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782408-B2 | Modulators of cystic fibrosis transmembrane conductance regulator | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-10-10 | — | — | US | disclosed |
| EP-2900645-A1 | 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION | Bayer CropScience AG (DE) | 2015-08-05 | — | — | EP | disclosed |