Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HK1 | P19367 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1185391 | 0.80 | NPC1 (0.59) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL16963507 | 0.75 | TGM2 (0.50) | LRRK2MEN1MAPTKMT2AHSP90AA1 | |
| SCHEMBL7438461 | 0.73 | MAPT (0.61) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL5525094 | 0.73 | MAPT (0.56) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL21311994 | 0.73 | LRRK2 (0.58) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL7404124 | 0.72 | CA12 (0.55) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL16963878 | 0.72 | PDE3B (0.61) | LRRK2MAOAMAOBKDM4EMEN1 | |
| SCHEMBL88725 | 0.71 | MEN1 (0.65) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL855431 | 0.71 | MAOA (0.56) | MAOAMAOBKDM4EMEN1MAPT | |
| SCHEMBL29385474 | 0.71 | MAOA (0.56) | MAOAMAOBKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663523-B2 | BET protein-inhibiting 5-aryltriazoleazepines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| US-9663523-B2 | BET protein-inhibiting 5-aryltriazoleazepines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| US-9663523-B2 | BET protein-inhibiting 5-aryltriazoleazepines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| EP-2900672-B1 | BET-PROTEIN INHIBITORY 5-ARYL-TRIAZOLO-AZEPINES | Bayer Pharma AG (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-2900672-B1 | BET-PROTEIN INHIBITORY 5-ARYL-TRIAZOLO-AZEPINES | Bayer Pharma AG (DE) | 2017-02-22 | — | — | EP | disclosed |
| US-20150299201-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-22 | — | — | US | disclosed |
| US-20150299201-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-22 | — | — | US | disclosed |
| US-20150299201-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-22 | — | — | US | disclosed |
| EP-2900672-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | Bayer Pharma Aktiengesellschaft (DE) | 2015-08-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299201-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | BRD4, BRDT, BET1 | LRRK2 768/4885MAOA 4579/4885MAOB 4387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.