Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 17/20 | 0.63 |
| ▸ | MET | P08581 | 13/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886578 | 0.88 | INSR (0.71) | INSRMETALK | |
| SCHEMBL16966123 | 0.84 | MET (0.59) | INSRMETALKBRD4 | |
| SCHEMBL16966243 | 0.83 | INSR (0.66) | INSRMETALK | |
| SCHEMBL16966171 | 0.81 | MET (0.67) | INSRMETALKBRD4 | |
| SCHEMBL885888 | 0.78 | INSR (0.81) | INSRMETALK | |
| SCHEMBL16966178 | 0.78 | MET (0.60) | INSRMET | |
| SCHEMBL885999 | 0.77 | MET (1.00) | INSRMETALK | |
| SCHEMBL2937031 | 0.76 | INSR (0.77) | INSRMETALK | |
| SCHEMBL884619 | 0.76 | INSR (0.86) | INSRMETALK | |
| SCHEMBL886602 | 0.75 | INSR (0.76) | INSRMETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | claimed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | claimed |