Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.58 |
| ▸ | PPARA | Q07869 | 10/20 | 0.45 |
| ▸ | PPARD | Q03181 | 6/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1319853 | 0.88 | AURKA (0.52) | AURKAPDPK1AURKBPPARAPPARD | |
| SCHEMBL12122733 | 0.85 | AURKA (0.60) | AURKAPDPK1AURKBSYK | |
| SCHEMBL1318005 | 0.84 | PDPK1 (0.83) | AURKAPDPK1AURKBPIK3CGROCK1 | |
| SCHEMBL16966441 | 0.78 | KDM1A (0.45) | AURKAPDPK1AURKBSYK | |
| SCHEMBL13354719 | 0.77 | PDPK1 (0.51) | AURKAPDPK1AURKBKMT2AMEN1 | |
| SCHEMBL3131514 | 0.75 | CCNC (0.40) | AURKAPDPK1AURKBPPARAPPARD | |
| SCHEMBL16966483 | 0.74 | PDPK1 (0.68) | AURKAPDPK1AURKBPIK3CGROCK1 | |
| SCHEMBL1320925 | 0.74 | PDPK1 (1.00) | AURKAPDPK1AURKBROCK1 | |
| SCHEMBL12119796 | 0.73 | AURKA (0.54) | AURKAPDPK1AURKBSYK | |
| SCHEMBL13354797 | 0.71 | PDPK1 (0.60) | AURKAPDPK1AURKBPIK3CGROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |