Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.62 |
| ▸ | ACAT1 | P24752 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638508 | 0.93 | DGAT1 (0.72) | DGAT1ACAT1 | |
| SCHEMBL16969528 | 0.92 | DGAT1 (0.71) | DGAT1ACAT1 | |
| SCHEMBL16969172 | 0.90 | DGAT1 (0.57) | DGAT1ACAT1 | |
| SCHEMBL16985182 | 0.89 | DGAT1 (0.62) | DGAT1ACAT1MAPT | |
| SCHEMBL16969504 | 0.87 | DGAT1 (0.81) | DGAT1ACAT1 | |
| SCHEMBL16969194 | 0.86 | DGAT1 (0.65) | DGAT1ACAT1 | |
| SCHEMBL16969236 | 0.84 | DGAT1 (0.65) | DGAT1ACAT1 | |
| SCHEMBL15638526 | 0.84 | DGAT1 (0.58) | DGAT1ACAT1 | |
| SCHEMBL3538508 | 0.84 | DGAT1 (0.72) | DGAT1CYP1A2MAPTCYP2C19 | |
| SCHEMBL3542035 | 0.84 | DGAT1 (0.83) | DGAT1CYP1A2MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550793-B2 | Spirocyclic compounds, compositions and medicinal applications thereof | ADVINUS THERAPEUTICS LIMITED (IN) | 2017-01-24 | — | — | US | claimed |
| EP-2903985-A1 | SPIROCYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | Advinus Therapeutics Limited (IN) | 2015-08-12 | — | — | EP | claimed |
| US-20150218187-A1 | SPIROCYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | IMPETIS BIOSCIENCES LTD. (IN) | 2015-08-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218187-A1 | SPIROCYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | DGAT1, DGAT2, CPT1A | DGAT1 1/4885ACAT1 8/4885CYP1A2 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.