Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3546289 | 0.92 | DGAT1 (0.80) | DGAT1L3MBTL1 | |
| SCHEMBL3544008 | 0.92 | DGAT1 (0.80) | DGAT1L3MBTL1RAB9A | |
| SCHEMBL3538131 | 0.91 | DGAT1 (0.80) | DGAT1L3MBTL1RAB9AMAPT | |
| SCHEMBL3550545 | 0.90 | DGAT1 (0.66) | DGAT1L3MBTL1RAB9ACYP1A2MAPT | |
| SCHEMBL3542035 | 0.90 | DGAT1 (0.83) | DGAT1CYP1A2MAPTCYP2C19 | |
| SCHEMBL3543813 | 0.90 | DGAT1 (0.83) | DGAT1L3MBTL1RAB9A | |
| SCHEMBL3549770 | 0.89 | DGAT1 (0.71) | DGAT1L3MBTL1RAB9ACYP1A2MAPT | |
| SCHEMBL3546452 | 0.86 | DGAT1 (0.72) | DGAT1L3MBTL1 | |
| SCHEMBL3539881 | 0.85 | DGAT1 (0.68) | DGAT1 | |
| SCHEMBL3543905 | 0.85 | DGAT1 (0.84) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317653-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2010-12-16 | — | — | US | disclosed |
| US-7795283-B2 | Oxadiazole derivative as DGAT inhibitors | ASTRAZENECA AB (SE) | 2010-09-14 | — | — | US | disclosed |
| US-20080096874-A1 | Oxadiazole Derivative as Dgat Inhibitors | ASTRAZENECA AB (SE) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317653-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | DGAT1, DGAT2, GPR119 | DGAT1 1/4885L3MBTL1 1959/4885RAB9A 2923/4885 |
| US-20080096874-A1 | Oxadiazole Derivative as Dgat Inhibitors | DGAT1, DGAT2, GPR119 | DGAT1 1/4885L3MBTL1 2007/4885RAB9A 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.