SCHEMBL16970552

SCHEMBL16970552

N[C@@H](COC(F)F)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MME P08473 7/20 0.55
▸ ACE P12821 5/20 0.50
▸ CPA1 P15085 5/20 0.50
▸ ACE2 Q9BYF1 5/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL15569275 0.99 MME (0.53) MMEACECPA1ACE2
SCHEMBL16970563 0.91 LTA4H (0.54) MMEACECPA1ACE2
SCHEMBL16970529 0.90 CTSC (0.51) MMEACECPA1ACE2
SCHEMBL16925150 0.88 MME (0.50) MMEACE
SCHEMBL16970536 0.87 CTSC (0.49) MMEACECPA1ACE2
SCHEMBL16970535 0.87 ACE (0.47) MMEACECPA1ACE2
SCHEMBL16970519 0.87 ACE (0.54) MMEACECPA1ACE2
SCHEMBL16984895 0.85 MME (0.48) MMEACE
SCHEMBL1329567 0.83 MME (0.67) MMEACECPA1ACE2
SCHEMBL5065345 0.83 MME (0.67) MMEACECPA1ACE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150218212-A1 FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS FLUORINOV PHARMA INC. (CA) 2015-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150218212-A1 FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS PSMA1, PSMB1, PSMB11 MME 192/4885ACE 1134/4885CPA1 732/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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