Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16972689 | 0.87 | KCNH2 (0.77) | KCNH2MCHR1PDGFRBFGFR1KDR | |
| SCHEMBL16972715 | 0.86 | KCNH2 (0.76) | KCNH2MCHR1 | |
| SCHEMBL16984241 | 0.86 | KCNH2 (0.76) | KCNH2SYK | |
| SCHEMBL16972717 | 0.86 | KCNH2 (0.76) | KCNH2SYK | |
| SCHEMBL16984185 | 0.85 | KCNH2 (0.75) | KCNH2MCHR1PDGFRBFGFR1KDR | |
| SCHEMBL16972707 | 0.85 | KCNH2 (0.73) | KCNH2MCHR1 | |
| SCHEMBL16984195 | 0.85 | KCNH2 (0.73) | KCNH2MCHR1 | |
| SCHEMBL16984191 | 0.84 | KCNH2 (0.72) | KCNH2 | |
| SCHEMBL16972681 | 0.81 | KCNH2 (0.69) | KCNH2MCHR1PDGFRBFGFR1KDR | |
| SCHEMBL16984239 | 0.81 | KCNH2 (0.68) | KCNH2MCHR1PDGFRBFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015114317-A1 | 5H-ISOTHIAZOLO[4,5-C]PYRIDINE-3,4-DIONE OR 5H-PYRAZOLO[4,3-C]PYRIDIN-3,4-DIONE AS ANTIBACTERIAL COMPOUNDS | REDX PHARMA PLC (GB) | 2015-08-06 | — | — | WO | disclosed |
| WO-2015114317-A1 | 5H-ISOTHIAZOLO[4,5-C]PYRIDINE-3,4-DIONE OR 5H-PYRAZOLO[4,3-C]PYRIDIN-3,4-DIONE AS ANTIBACTERIAL COMPOUNDS | REDX PHARMA PLC (GB) | 2015-08-06 | — | — | WO | disclosed |