Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 12/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16984239 | 0.82 | KCNH2 (0.68) | KCNH2MCHR1SYKPDGFRBFGFR1 | |
| SCHEMBL14758924 | 0.77 | KCNH2 (0.62) | KCNH2MCHR1TLR9TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL14745204 | 0.76 | KCNH2 (0.61) | KCNH2MCHR1TLR9TLR8TLR7 | |
| SCHEMBL16972703 | 0.75 | KCNH2 (1.00) | KCNH2MCHR1SYKPDGFRBFGFR1 | |
| SCHEMBL16972737 | 0.74 | KCNH2 (0.59) | KCNH2MCHR1TLR9TLR8TLR7 | |
| SCHEMBL14745687 | 0.69 | KCNH2 (0.57) | KCNH2MCHR1PDGFRBFGFR1KDR | |
| SCHEMBL14758820 | 0.69 | KCNH2 (0.57) | KCNH2MCHR1PDGFRBFGFR1KDR | |
| SCHEMBL14758835 | 0.69 | KCNH2 (0.57) | KCNH2MCHR1PDGFRBFGFR1KDR | |
| SCHEMBL16567839 | 0.69 | KCNH2 (0.61) | KCNH2MCHR1SYKPDGFRBFGFR1 | |
| Hydrochloric Acid SCHEMBL14745362 | 0.69 | KCNH2 (0.56) | KCNH2MCHR1PDGFRBFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015114317-A1 | 5H-ISOTHIAZOLO[4,5-C]PYRIDINE-3,4-DIONE OR 5H-PYRAZOLO[4,3-C]PYRIDIN-3,4-DIONE AS ANTIBACTERIAL COMPOUNDS | REDX PHARMA PLC (GB) | 2015-08-06 | — | — | WO | disclosed |