Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 5/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16973678 | 0.88 | DYRK1A (0.51) | DYRK1AWNT1ACKR3PRKAA2PRKAB2 | |
| SCHEMBL16973764 | 0.84 | GRM5 (0.40) | DYRK1AGRM5WNT1CTSAPRKAA2 | |
| SCHEMBL16973650 | 0.83 | GRM5 (0.39) | GRM5CTSAPRKAA2S1PR3CD38 | |
| SCHEMBL16973837 | 0.81 | JUN (0.40) | DYRK1AACKR3PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL16973824 | 0.81 | GRM5 (0.43) | GRM5CTSAPRKAA2S1PR3PRKAB2 | |
| SCHEMBL16973738 | 0.75 | DYRK1A (0.51) | DYRK1AWNT1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL19784084 | 0.74 | CNR1 (0.50) | GRM5CD38 | |
| SCHEMBL16973679 | 0.74 | PRKAA2 (0.43) | DYRK1APRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL16984569 | 0.74 | USP30 (0.48) | — | |
| SCHEMBL16973716 | 0.74 | HPGDS (0.51) | DYRK1AWNT1PRKAA2PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015113927-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-08-06 | — | — | WO | disclosed |
| WO-2015113927-A1 | AMINO-SUBSTITUTED ISOTHIAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-08-06 | — | — | WO | disclosed |