Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15564595 | 0.80 | MMP2 (0.41) | MMES1PR1AGTR2S1PR3SMN1; SMN2 | |
| SCHEMBL15563645 | 0.79 | MMEL1 (0.44) | MMES1PR1 | |
| SCHEMBL16975133 | 0.79 | MME (0.42) | MMEACES1PR1AGTR2SMN1; SMN2 | |
| SCHEMBL19355072 | 0.77 | MME (0.45) | MMEACE | |
| SCHEMBL16974296 | 0.76 | MMP2 (0.43) | MMEACEAGTR2 | |
| SCHEMBL12481770 | 0.75 | MME (0.42) | MMEACES1PR1S1PR3 | |
| SCHEMBL16974298 | 0.75 | MME (0.37) | MMEACESMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL18000007 | 0.75 | MME (0.45) | MMEACE | |
| SCHEMBL15563835 | 0.73 | MME (0.44) | MMEACEAGTR2 | |
| SCHEMBL18000010 | 0.73 | MME (0.45) | MMEACESMN1; SMN2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099668-A1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116760-A1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |