Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 5/20 | 0.43 |
| ▸ | MME | P08473 | 14/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15563835 | 0.88 | MME (0.44) | MMP2MMP3MMEACEAGTR2 | |
| SCHEMBL17980322 | 0.84 | MMP2 (0.41) | MMP2MMP3MMEACE | |
| SCHEMBL15564592 | 0.82 | MMP3 (0.52) | MMP2MMP3MME | |
| SCHEMBL15563642 | 0.81 | MMEL1 (0.49) | MMP2MMP3MMEACE | |
| SCHEMBL16974298 | 0.79 | MME (0.37) | MMEACE | |
| SCHEMBL12481766 | 0.77 | MMP2 (0.52) | MMP2MMP3MMEACE | |
| SCHEMBL16974299 | 0.76 | MME (0.39) | MMEACEAGTR2 | |
| SCHEMBL15564104 | 0.76 | MMEL1 (0.46) | MMP2MMP3MME | |
| SCHEMBL6684832 | 0.73 | TGM2 (0.49) | MMP2MMP3 | |
| SCHEMBL19355072 | 0.72 | MME (0.45) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099668-A1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015116760-A1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |