Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16974905 | 0.88 | ALDH1A1 (0.46) | CYP1A2BCHEACHENOX1SMN1; SMN2 | |
| SCHEMBL16974835 | 0.87 | CYP1A2 (0.47) | PKMCYP1A2CNR1LMNASMN1; SMN2 | |
| SCHEMBL8664923 | 0.86 | CYP1A2 (0.43) | PKMCYP1A2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL16974908 | 0.83 | CYP1A2 (0.42) | PKMCYP1A2CNR1LMNASMN1; SMN2 | |
| SCHEMBL16974849 | 0.83 | CYP1A2 (0.44) | PKMCYP1A2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL16974883 | 0.80 | KDM4E (0.39) | BCHEACHENOX1SMN1; SMN2KDM4E | |
| SCHEMBL16974823 | 0.79 | ALDH1A1 (0.46) | PKMCYP1A2BCHEACHESMN1; SMN2 | |
| SCHEMBL16974854 | 0.79 | HDAC8 (0.41) | BCHEACHENOX1SMN1; SMN2KDM4E | |
| SCHEMBL7954366 | 0.76 | PKM (0.48) | PKMCYP1A2CNR1LMNASMN1; SMN2 | |
| SCHEMBL8585833 | 0.76 | CYP1A2 (0.39) | CYP1A2LMNABCHEACHENOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099304-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | Mayo Foundation for Medical Education and Research (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015117024-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-08-06 | — | — | WO | disclosed |