Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16974903 | 0.90 | GSK3B (0.40) | KDM4EGSK3BNOX1BCHEACHE | |
| SCHEMBL16974887 | 0.86 | GSK3B (0.36) | KDM4EGSK3BTAAR1HTTSMN1; SMN2 | |
| SCHEMBL16974854 | 0.86 | HDAC8 (0.41) | KDM4EGSK3BNOX1BCHEACHE | |
| SCHEMBL16974842 | 0.85 | CCNT1 (0.34) | KDM4EGSK3BBCHEACHEHTT | |
| SCHEMBL16974918 | 0.81 | ALDH1A1 (0.34) | KDM4EGSK3BHTTSMN1; SMN2KCNH3 | |
| SCHEMBL16974865 | 0.80 | PKM (0.47) | KDM4ENOX1BCHEACHETAAR1 | |
| SCHEMBL8583938 | 0.79 | CCNC (0.43) | KDM4ENOX1BCHEACHETAAR1 | |
| SCHEMBL8585833 | 0.79 | CYP1A2 (0.39) | KDM4ENOX1BCHEACHEHTT | |
| SCHEMBL16974874 | 0.78 | NOX1 (0.37) | GSK3BNOX1TAAR1HTTSMN1; SMN2 | |
| SCHEMBL16974838 | 0.78 | ROCK2 (0.40) | KDM4EGSK3BTAAR1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099304-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | Mayo Foundation for Medical Education and Research (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015117024-A1 | NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-08-06 | — | — | WO | disclosed |