Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.52 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL16975014 | 0.92 | ALDH1A1 (0.50) | ALDH1A1EHMT2EHMT1APOBEC3GKMT2A | |
| SCHEMBL35924 | 0.89 | — | — | |
| Acrylic Acid SCHEMBL1500467 | 0.87 | ALDH1A1 (0.46) | ALDH1A1EHMT2EHMT1APOBEC3GKMT2A | |
| Propionic Acid SCHEMBL6660723 | 0.87 | ALDH1A1 (0.54) | ALDH1A1EHMT2EHMT1APOBEC3GKMT2A | |
| Ammonia Solution, Strong SCHEMBL7972300 | 0.87 | — | — | |
| SCHEMBL28128254 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL10707245 | 0.87 | — | — | |
| Methacrylic Acid SCHEMBL421102 | 0.86 | ALDH1A1 (0.45) | ALDH1A1EHMT2EHMT1APOBEC3GKMT2A | |
| Pyridine SCHEMBL27614389 | 0.85 | EHMT2 (0.54) | ALDH1A1EHMT2EHMT1APOBEC3GKMT2A | |
| Ethylene Glycol SCHEMBL5087076 | 0.83 | EHMT2 (0.52) | ALDH1A1EHMT2EHMT1APOBEC3GKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928796-A1 | SMALL MOLECULE DRUG CONJUGATES | Eidgenöessische Technische Hochschule Zurich (CH) | 2021-12-29 | — | — | EP | disclosed |
| US-11180522-B2 | Disulfide-linked reversible terminators | CENTRILLION TECHNOLOGY HOLDINGS CORPORATION (KY) | 2021-11-23 | — | — | US | disclosed |
| EP-3730154-B1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSICHE TECHNISCHE HOCHSCHULE ZUERICH (CH) | 2021-06-30 | — | — | EP | disclosed |
| EP-3424537-B1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSICHE TECHNISCHE HOCHSCHULE ZUERICH (CH) | 2021-01-13 | — | — | EP | disclosed |
| EP-3730154-A1 | SMALL MOLECULE DRUG CONJUGATES | Eidgenössiche Technische Hochschule Zürich (CH) | 2020-10-28 | — | — | EP | disclosed |
| EP-3102241-B1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSICHE TECHNISCHE HOCHSCHULE ZUERICH (CH) | 2019-04-17 | — | — | EP | disclosed |
| EP-3091026-B1 | DISULFIDE-LINKED REVERSIBLE TERMINATORS | CENTRILLION TECH HOLDINGS CORP (KY) | 2019-02-20 | — | — | EP | disclosed |
| EP-3424537-A1 | SMALL MOLECULE DRUG CONJUGATES | Eidgenössiche Technische Hochschule Zürich (CH) | 2019-01-09 | — | — | EP | disclosed |
| EP-3102241-A1 | SMALL MOLECULE DRUG CONJUGATES | Eidgenössiche Technische Hochschule Zürich (CH) | 2016-12-14 | — | — | EP | disclosed |
| US-20160355541-A1 | DISULFIDE-LINKED REVERSIBLE TERMINATORS | CENTRILLION TECHNOLOGY HOLDINGS CORPORATION (KY) | 2016-12-08 | — | — | US | disclosed |
| WO-2016182984-A1 | DISULFIDE-LINKED REVERSIBLE TERMINATORS | CENTRILLION TECHNOLOGY HOLDINGS CORPORATION (KY) | 2016-11-17 | — | — | WO | disclosed |
| EP-3091026-A1 | DISULFIDE-LINKED REVERSIBLE TERMINATORS | Centrillion Technology Holdings Corporation (KY) | 2016-11-09 | — | — | EP | disclosed |
| WO-2015114171-A1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) | 2015-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180522-B2 | Disulfide-linked reversible terminators | RNGTT, NSUN3, NSUN2 | ALDH1A1 3688/4885EHMT2 3291/4885EHMT1 2672/4885 |
| US-20160355541-A1 | DISULFIDE-LINKED REVERSIBLE TERMINATORS | RNGTT, NSUN2, NSUN3 | ALDH1A1 3864/4885EHMT2 2497/4885EHMT1 2670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.