Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062318 | 0.75 | RYR2 (0.59) | RYR2KCNH2PNMTMEN1ALDH1A1 | |
| SCHEMBL14691898 | 0.75 | RYR2 (0.59) | RYR2KCNH2PNMTMEN1ALDH1A1 | |
| SCHEMBL8134941 | 0.75 | RYR2 (0.59) | RYR2KCNH2PNMTMEN1ALDH1A1 | |
| SCHEMBL28461427 | 0.75 | RYR2 (0.59) | RYR2KCNH2PNMT | |
| SCHEMBL2600211 | 0.75 | RYR2 (0.64) | RYR2KCNH2PNMTMEN1KMT2A | |
| SCHEMBL8244272 | 0.74 | RYR2 (0.55) | RYR2KCNH2PNMTMEN1ALDH1A1 | |
| SCHEMBL10263631 | 0.73 | PNMT (0.63) | PNMTNOS3 | |
| SCHEMBL28137126 | 0.73 | ASIC3 (0.55) | PNMT | |
| SCHEMBL2062141 | 0.72 | PNMT (0.59) | RYR2KCNH2PNMTALDH1A1 | |
| SCHEMBL10289477 | 0.71 | PNMT (0.43) | PNMTALDH1A1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | disclosed |