Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824838 | 0.78 | ALDH1A1 (0.40) | CYP2A6ALDH1A1MEN1GAAMAPT | |
| SCHEMBL10366338 | 0.75 | ALDH1A1 (0.45) | CYP2A6ALDH1A1MEN1GAAMAPT | |
| SCHEMBL28461427 | 0.75 | RYR2 (0.59) | RYR2KCNH2MAPTKDM4EPNMT | |
| SCHEMBL2600211 | 0.75 | RYR2 (0.64) | RYR2KCNH2MEN1MAPTKMT2A | |
| SCHEMBL8134941 | 0.75 | RYR2 (0.59) | RYR2KCNH2ALDH1A1MEN1GAA | |
| SCHEMBL2062318 | 0.75 | RYR2 (0.59) | RYR2KCNH2ALDH1A1MEN1GAA | |
| SCHEMBL14691898 | 0.75 | RYR2 (0.59) | RYR2KCNH2ALDH1A1MEN1GAA | |
| SCHEMBL16976367 | 0.74 | RYR2 (0.55) | RYR2KCNH2ALDH1A1MEN1GAA | |
| SCHEMBL3054155 | 0.73 | ALDH1A1 (0.49) | RYR2KCNH2CYP2A6ALDH1A1MEN1 | |
| SCHEMBL3944638 | 0.73 | ASIC3 (0.55) | PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007024717-A2 | AGENTS FOR PREVENTING AND TREATING DISORDERS INVOLVING MODULATION OF THE RYR RECEPTORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2007-03-01 | — | — | WO | disclosed |