Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18470275 | 0.92 | KCNH2 (0.50) | KCNH2KDM4EPGRMAPTERN1 | |
| SCHEMBL18470267 | 0.85 | LTA4H (0.44) | KCNH2KDM4EPGRMAPTERN1 | |
| SCHEMBL20201645 | 0.84 | LIMK1 (0.46) | KCNH2KDM4EPGRMAPTERN1 | |
| SCHEMBL23046383 | 0.83 | KCNH2 (0.42) | KCNH2KDM4EPGRMAPTERN1 | |
| SCHEMBL17037106 | 0.83 | KCNH2 (0.42) | KCNH2KDM4EPGRMAPTERN1 | |
| SCHEMBL18470290 | 0.82 | KDM4E (0.50) | KCNH2KDM4EMAPTERN1LTA4H | |
| SCHEMBL23612711 | 0.81 | LIMK1 (0.46) | KCNH2KDM4EMAPTLTA4HALK | |
| SCHEMBL19916793 | 0.81 | PGR (0.39) | KCNH2KDM4EPGRMAPTSLC6A11 | |
| SCHEMBL15223448 | 0.81 | PGR (0.48) | KCNH2KDM4EPGRMAPTERN1 | |
| SCHEMBL15223464 | 0.81 | PGR (0.48) | KCNH2KDM4EPGRMAPTERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187493-B2 | Heterocyclic compound and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2015-11-17 | — | — | US | disclosed |
| US-9187493-B2 | Heterocyclic compound and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2015-11-17 | — | — | US | disclosed |
| US-20150218185-A1 | Heterocyclic Compound And Use Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2015-08-06 | — | — | US | disclosed |
| US-20150218185-A1 | Heterocyclic Compound And Use Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2015-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218185-A1 | Heterocyclic Compound And Use Thereof | CCNE1, CRY1, CCNE2 | KCNH2 1419/4885KDM4E 1764/4885PGR 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.