Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.61 |
| ▸ | SRC | P12931 | 8/20 | 0.61 |
| ▸ | EGFR | P00533 | 7/20 | 0.61 |
| ▸ | WEE1 | P30291 | 7/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 7/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL5761899 | 0.98 | FGFR1 (0.62) | FGFR1SRCEGFRWEE1FGFR2 | |
| Ethane SCHEMBL5793409 | 0.90 | WEE1 (0.54) | FGFR1SRCEGFRWEE1FGFR2 | |
| SCHEMBL14161581 | 0.89 | SRC (0.53) | FGFR1SRCEGFRWEE1FGFR2 | |
| SCHEMBL12856330 | 0.84 | ABL1 (0.69) | FGFR1SRCEGFRWEE1FGFR2 | |
| SCHEMBL13038777 | 0.84 | SYK (0.45) | FGFR1SRCEGFRWEE1FGFR2 | |
| SCHEMBL14161490 | 0.83 | SRC (0.53) | FGFR1SRCEGFRWEE1FGFR2 | |
| SCHEMBL10276720 | 0.80 | FGFR1 (0.65) | FGFR1SRCEGFRWEE1FGFR2 | |
| SCHEMBL16287646 | 0.79 | NPC1 (0.45) | FGFR1SRCEGFRWEE1FGFR2 | |
| SCHEMBL5619944 | 0.79 | SRC (0.56) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL1249524 | 0.76 | FGFR1 (1.00) | FGFR1SRCEGFRWEE1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015118110-A1 | PYRIDO[2,3-D]PYRIMIDINE-7(8H)-ONE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) | 2015-08-13 | — | — | WO | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |