Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 9/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.54 |
| ▸ | SRC | P12931 | 7/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 6/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.48 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL5761899 | 0.93 | FGFR1 (0.62) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL16986331 | 0.90 | FGFR1 (0.61) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL14161581 | 0.80 | SRC (0.53) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL12856330 | 0.78 | ABL1 (0.69) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL13038777 | 0.78 | SYK (0.45) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL5762216 | 0.77 | FGFR1 (0.87) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL14161490 | 0.77 | SRC (0.53) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL10276720 | 0.74 | FGFR1 (0.65) | WEE1FGFR1SRCEGFRFGFR2 | |
| SCHEMBL5619944 | 0.73 | SRC (0.56) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5764038 | 0.73 | FGFR1 (0.68) | WEE1FGFR1SRCEGFRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |