Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 4/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986309 | 0.89 | KCNJ5 (0.34) | CCNA2CDK2HTR1AHTR2CHTR7 | |
| SCHEMBL16986358 | 0.83 | TP53 (0.36) | HTR1AHTR2CHTR7HTR5ATP53 | |
| SCHEMBL17001192 | 0.72 | KMT2A (0.39) | TP53NPC1 | |
| SCHEMBL16986350 | 0.71 | KCNH3 (0.36) | — | |
| SCHEMBL16310227 | 0.71 | TP53 (0.38) | HTR1AHTR2CHTR7HTR5ATP53 | |
| SCHEMBL16986334 | 0.65 | NPC1 (0.36) | HTR7NPC1 | |
| SCHEMBL16986308 | 0.65 | FGFR1 (0.39) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL16986312 | 0.64 | FGFR1 (0.55) | — | |
| SCHEMBL16986328 | 0.61 | HSP90AA1 (0.37) | TP53 | |
| SCHEMBL16986300 | 0.61 | TP53 (0.37) | TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015118110-A1 | PYRIDO[2,3-D]PYRIMIDINE-7(8H)-ONE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) | 2015-08-13 | — | — | WO | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |