Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.39 |
| ▸ | SRC | P12931 | 6/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986312 | 0.80 | FGFR1 (0.55) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL16986359 | 0.76 | DHFR (0.41) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL16986327 | 0.74 | FGFR1 (0.46) | FGFR1SRCEGFR | |
| SCHEMBL16986323 | 0.70 | FGFR1 (0.40) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5619944 | 0.69 | SRC (0.56) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL16986348 | 0.65 | CDK1 (0.35) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL16986355 | 0.65 | PIK3CA (0.39) | PDE5A | |
| SCHEMBL16993894 | 0.64 | L3MBTL1 (0.39) | — | |
| SCHEMBL16287646 | 0.63 | NPC1 (0.45) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5659394 | 0.60 | FGFR1 (0.45) | FGFR1SRCBTKEGFRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015118110-A1 | PYRIDO[2,3-D]PYRIMIDINE-7(8H)-ONE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) | 2015-08-13 | — | — | WO | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |
| EP-2905024-A1 | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | Institut Quimic De Sarriá Cets, Fundació Privada (ES) | 2015-08-12 | — | — | EP | disclosed |