Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.52 |
| ▸ | PPARG | P37231 | 7/20 | 0.52 |
| ▸ | PPARD | Q03181 | 7/20 | 0.52 |
| ▸ | PPARA | Q07869 | 7/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25236455 | 1.00 | CES2 (0.54) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL4986153 | 1.00 | CES2 (0.54) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL28785208 | 1.00 | CES2 (0.54) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL1555533 | 1.00 | CES2 (0.54) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL16987399 | 1.00 | CES2 (0.54) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL11327410 | 0.98 | CES2 (0.52) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL11327481 | 0.90 | CES1 (0.50) | CES2CES1ALDH1A1LPAR2LPAR3 | |
| SCHEMBL10445613 | 0.88 | FABP3 (0.65) | PPARGPPARDPPARAPTPN1TDP1 | |
| SCHEMBL27670934 | 0.88 | FABP3 (0.65) | PPARGPPARDPPARAPTPN1TDP1 | |
| SCHEMBL304736 | 0.88 | FABP3 (0.65) | PPARGPPARDPPARAPTPN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9930893-B2 | Inhibitors of DXP synthase and methods of use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-04-03 | — | — | US | disclosed |
| US-20150225430-A1 | INHIBITORS OF DXP SYNTHASE AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225430-A1 | INHIBITORS OF DXP SYNTHASE AND METHODS OF USE THEREOF | DHPS, FDPS, DPYD | CES2 314/4885CES1 146/4885GPR84 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.