Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20993075 | 0.78 | CAMK2A (0.36) | — | |
| SCHEMBL27944326 | 0.74 | — | — | |
| SCHEMBL1803732 | 0.74 | — | — | |
| SCHEMBL27900863 | 0.73 | — | — | |
| SCHEMBL982455 | 0.72 | CES2 (0.50) | CES2CES1HDAC3HDAC1HDAC2 | |
| SCHEMBL29064899 | 0.72 | FFAR3 (0.38) | FFAR3ALDH1A1 | |
| SCHEMBL11716989 | 0.71 | — | — | |
| SCHEMBL7267287 | 0.71 | — | — | |
| SCHEMBL11727566 | 0.70 | CES1 (0.43) | CES2CES1HDAC3HDAC1HDAC2 | |
| SCHEMBL11556450 | 0.70 | CES1 (0.43) | CES2CES1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663366-B1 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2025-01-08 | — | — | EP | disclosed |
| CN-111053775-B | Physiologically cool active ingredient and use of substances containing such active ingredient | 西姆莱斯股份公司 | 2023-08-18 | — | — | CN | disclosed |
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |
| EP-3663366-A2 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | Symrise AG (DE) | 2020-06-10 | — | — | EP | disclosed |
| CN-111053775-A | Physiologically cooling active ingredients and use of substances containing such active ingredients | 西姆莱斯股份公司 | 2020-04-24 | — | — | CN | disclosed |
| US-10584134-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2020-03-10 | — | — | US | disclosed |
| CN-102844386-B | Physiologically cooling active ingredients and use of substances containing such active ingredients | 西姆莱斯股份公司 | 2020-01-21 | — | — | CN | disclosed |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2018-04-05 | — | — | US | disclosed |
| US-9718839-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2017-08-01 | — | — | US | disclosed |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2015-03-26 | — | — | US | disclosed |
| US-8927605-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2015-01-06 | — | — | US | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| EP-2501761-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | Symrise AG (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061330-A9 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2012-01-05 | — | — | WO | disclosed |
| WO-2011061330-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | CES2 2166/4885CES1 2412/4885HDAC3 2747/4885 |
| US-10584134-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | TRPM8, TRPM7, TRPM2 | CES2 2166/4885CES1 2412/4885HDAC3 2747/4885 |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | CES2 2166/4885CES1 2412/4885HDAC3 2747/4885 |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | CES2 2166/4885CES1 2412/4885HDAC3 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.