Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.70 |
| ▸ | RAB9A | P51151 | 10/20 | 0.70 |
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | HPGD | P15428 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | CASP1 | P29466 | 1/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302856 | 0.95 | RAB9A (0.64) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL7564852 | 0.93 | RAB9A (0.79) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL9126319 | 0.93 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL7201367 | 0.90 | NPC1 (0.59) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL9126064 | 0.90 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL7195879 | 0.90 | NPC1 (0.59) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL9124310 | 0.90 | NPC1 (0.58) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL7197815 | 0.90 | NPC1 (0.58) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL13387589 | 0.88 | RAB9A (0.72) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL10361283 | 0.88 | NPC1 (0.54) | SMN1; SMN2RAB9ANPC1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |
| EP-0880502-A1 | AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028129-A1 | AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |