Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699227 | 0.84 | MEN1 (0.44) | MEN1KMT2AMAP3K11KDM4EGAA | |
| SCHEMBL1699234 | 0.81 | L3MBTL1 (0.54) | PIK3CACSNK2A1 | |
| SCHEMBL1699264 | 0.80 | MAP3K11 (0.40) | MEN1KMT2AMAP3K11KDM4EGAA | |
| SCHEMBL15385957 | 0.78 | MAP3K11 (0.41) | MEN1KMT2AMAP3K11KDM4EGAA | |
| SCHEMBL1699212 | 0.76 | MAP3K11 (0.40) | MEN1KMT2AMAP3K11KDM4EGAA | |
| SCHEMBL1699111 | 0.73 | PDE10A (0.36) | MEN1KMT2AHSD17B10USP2MAPK13 | |
| SCHEMBL1699627 | 0.72 | KDM4E (0.40) | MEN1KMT2AMAP3K11KDM4EGAA | |
| SCHEMBL1699169 | 0.72 | MAP3K11 (0.39) | MEN1KMT2AMAP3K11KDM4EGAA | |
| SCHEMBL1699077 | 0.70 | MAP3K11 (0.39) | MEN1KMT2AMAP3K11KDM4EGAA | |
| SCHEMBL1699349 | 0.70 | MAP3K11 (0.38) | MEN1KMT2AMAP3K11KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |