Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699169 | 0.86 | MAP3K11 (0.39) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL1699627 | 0.86 | KDM4E (0.40) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL1699212 | 0.84 | MAP3K11 (0.40) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL1699205 | 0.80 | MEN1 (0.43) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL1699077 | 0.78 | MAP3K11 (0.39) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL15385957 | 0.78 | MAP3K11 (0.41) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL1699349 | 0.77 | MAP3K11 (0.38) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL1699227 | 0.76 | MEN1 (0.44) | MAP3K11KDM4EHSD17B10GAAMAPK1 | |
| SCHEMBL1699226 | 0.73 | ALDH1A1 (0.35) | KDM4EHSD17B10MAPK1KMT2AMEN1 | |
| SCHEMBL725715 | 0.66 | MAP3K11 (0.48) | MAP3K11ESR1ESR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |