Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699476 | 0.80 | PDE10A (0.36) | PDE10ADRD1PDE4BLMNAHDAC1 | |
| SCHEMBL1699111 | 0.79 | PDE10A (0.36) | PDE10ADRD1PDE4BLMNAMEN1 | |
| SCHEMBL1699098 | 0.78 | DRD1 (0.44) | PDE10ADRD1PDE4BLMNAMEN1 | |
| SCHEMBL1699084 | 0.77 | DRD1 (0.39) | PDE10ADRD1PDE4BLMNAMEN1 | |
| SCHEMBL1699248 | 0.76 | DRD1 (0.38) | PDE10ADRD1PDE4BLMNAMEN1 | |
| SCHEMBL1699092 | 0.76 | DRD1 (0.38) | PDE10ADRD1PDE4BLMNAMEN1 | |
| SCHEMBL14889112 | 0.75 | DRD1 (0.38) | PDE10ADRD1PDE4BLMNAMEN1 | |
| SCHEMBL1699557 | 0.73 | HDAC1 (0.37) | PDE10ADRD1LMNAMEN1ALDH1A1 | |
| SCHEMBL9981648 | 0.72 | PDE10A (0.41) | PDE10APDE4BLMNAALDH1A1TSHR | |
| SCHEMBL9980896 | 0.72 | PDE10A (0.41) | PDE10APDE4BLMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |