Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699098 | 0.89 | DRD1 (0.44) | DRD1PDE10AMEN1KMT2APOLB | |
| SCHEMBL1699084 | 0.88 | DRD1 (0.39) | DRD1PDE10AMEN1KMT2APOLB | |
| SCHEMBL1699248 | 0.87 | DRD1 (0.38) | DRD1PDE10AMEN1KMT2APOLB | |
| SCHEMBL1699557 | 0.83 | HDAC1 (0.37) | DRD1PDE10AMEN1KMT2APOLB | |
| SCHEMBL14889112 | 0.82 | DRD1 (0.38) | DRD1PDE10AMEN1KMT2APOLB | |
| SCHEMBL1699111 | 0.79 | PDE10A (0.36) | DRD1PDE10AMEN1KMT2APOLB | |
| SCHEMBL1699476 | 0.79 | PDE10A (0.36) | DRD1PDE10ALMNAPDE4BHDAC1 | |
| SCHEMBL1699250 | 0.76 | PDE10A (0.36) | DRD1PDE10AMEN1KMT2ALMNA | |
| SCHEMBL14333706 | 0.74 | ALDH1A1 (0.37) | DRD1KMT2APOLBLMNAALDH1A1 | |
| SCHEMBL1702837 | 0.73 | NCOA3 (0.37) | PDE10AMEN1KMT2APOLBPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |