Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL236945 | 0.83 | CCR1 (0.34) | ATRSMN1; SMN2LMNAKDM4EASPH | |
| SCHEMBL23854582 | 0.79 | KDM5A (0.35) | ATRKDM4EASPHKDM8KDM5A | |
| SCHEMBL8802786 | 0.75 | ALDH1A1 (0.38) | LMNAKDM4EALDH1A1NPSR1 | |
| SCHEMBL14909183 | 0.75 | KDM4E (0.39) | ATRSMN1; SMN2LMNAKDM4EASPH | |
| SCHEMBL238763 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAKDM4ETDP1ALDH1A1 | |
| SCHEMBL1350020 | 0.74 | ATR (0.34) | ATRSMN1; SMN2LMNAKDM4EASPH | |
| SCHEMBL1094625 | 0.71 | L3MBTL1 (0.42) | SMN1; SMN2LMNACNR2KMOALDH1A1 | |
| SCHEMBL71090 | 0.71 | SMARCA2 (0.41) | ATRKDM4ECNR2FFAR1ALDH1A1 | |
| SCHEMBL6705128 | 0.71 | ATR (0.32) | ATRSMN1; SMN2LMNAFFAR1TDP1 | |
| SCHEMBL7410941 | 0.70 | HTT (0.45) | LMNAKDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |