Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18530347 | 1.00 | TDP1 (0.36) | TDP1P2RX7CTSLMEN1MAPK1 | |
| SCHEMBL14813442 | 0.89 | CA12 (0.33) | P2RX7CTSLMEN1MAPK1KMT2A | |
| SCHEMBL13738955 | 0.88 | P2RX7 (0.34) | TDP1P2RX7CTSLMEN1MAPK1 | |
| SCHEMBL4726064 | 0.88 | P2RX7 (0.34) | TDP1P2RX7CTSLMEN1MAPK1 | |
| SCHEMBL3942864 | 0.85 | P2RX7 (0.34) | TDP1P2RX7CTSLMEN1MAPK1 | |
| SCHEMBL13738101 | 0.85 | P2RX7 (0.34) | TDP1P2RX7CTSLMEN1MAPK1 | |
| SCHEMBL8568717 | 0.84 | APLNR (0.34) | TDP1P2RX7CTSLMEN1MAPK1 | |
| SCHEMBL3369497 | 0.83 | TDP1 (0.42) | TDP1P2RX7CTSLMEN1MAPK1 | |
| SCHEMBL9175696 | 0.83 | P2RX7 (0.33) | P2RX7CTSLMEN1MAPK1KMT2A | |
| SCHEMBL19278457 | 0.83 | P2RX7 (0.31) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102577-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS | Principia Biopharma Inc. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015120049-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS | PRINCIPIA BIOPHARMA, INC. (US) | 2015-08-13 | — | — | WO | disclosed |