Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PPIA | P62937 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13738101 | 1.00 | P2RX7 (0.34) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL6703818 | 0.91 | P2RX7 (0.35) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL14813442 | 0.88 | CA12 (0.33) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL13738955 | 0.88 | P2RX7 (0.34) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL4726064 | 0.88 | P2RX7 (0.34) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL8568717 | 0.87 | APLNR (0.34) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| Hydrochloric Acid SCHEMBL23043372 | 0.86 | KMT2A (0.38) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL16993451 | 0.85 | TDP1 (0.36) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL9175696 | 0.85 | P2RX7 (0.33) | P2RX7KMT2ACTSLMEN1MAPK1 | |
| SCHEMBL18530347 | 0.85 | TDP1 (0.36) | P2RX7KMT2ACTSLMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |