Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.35 |
| ▸ | PPARA | Q07869 | 6/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27903975 | 0.91 | NOD2 (0.37) | NOD2NOD1POLBMEN1ALDH1A1 | |
| SCHEMBL27903964 | 0.88 | GPR84 (0.39) | PTPN1PPARGPPARACTRCKCNH2 | |
| SCHEMBL27921758 | 0.86 | PPARG (0.33) | PTPN1PPARGPPARAPPARDCTRC | |
| SCHEMBL27903959 | 0.84 | PTPN1 (0.40) | PTPN1PPARGPPARAPPARDPOLB | |
| SCHEMBL27903920 | 0.84 | PTPN1 (0.40) | PTPN1PPARGPPARAPOLBALDH1A1 | |
| SCHEMBL27903976 | 0.83 | DHODH (0.37) | PPARGPPARAPPARDCTRC | |
| SCHEMBL27921791 | 0.83 | CTRC (0.35) | PPARGPPARAPPARDCTRC | |
| SCHEMBL27903929 | 0.82 | PTPN1 (0.38) | PTPN1PPARGPPARAPPARDPOLB | |
| SCHEMBL27921901 | 0.82 | GCGR (0.40) | PTPN1PPARGPPARAPPARDPOLB | |
| SCHEMBL27921762 | 0.81 | CTRC (0.39) | PPARGPPARAPPARDCTRCPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103140474-A | Naphthalen-2-ylacetic acid derivatives for the treatment of AIDS | GILEAD SCIENCES INC | 2013-06-05 | — | — | CN | disclosed |
| EP-2588450-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |