Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557280 | 0.81 | CYSLTR1 (0.34) | NAMPT | |
| SCHEMBL12195355 | 0.80 | HDAC1 (0.31) | — | |
| SCHEMBL12831690 | 0.79 | NAMPT (0.30) | NAMPT | |
| SCHEMBL17578357 | 0.79 | CA2 (0.33) | NAMPT | |
| SCHEMBL5986203 | 0.78 | ALDH1A1 (0.32) | — | |
| SCHEMBL18468549 | 0.76 | TDP1 (0.33) | — | |
| SCHEMBL23349282 | 0.75 | HSP90AB1 (0.39) | — | |
| SCHEMBL13845850 | 0.75 | ALDH1A1 (0.40) | — | |
| SCHEMBL19888619 | 0.75 | CYP1A2 (0.36) | — | |
| SCHEMBL19888586 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | disclosed |