SCHEMBL1699530

SCHEMBL1699530

O=c1[nH]c2cc(O)cnc2n1CCc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.45
CYP2C19 P33261 3/20 0.45
ALDH1A1 P00352 2/20 0.45
CYP2C9 P11712 2/20 0.45
TSHR P16473 2/20 0.45
CYP2D6 P10635 1/20 0.45
HRH3 Q9Y5N1 1/20 0.44
FFAR1 O14842 2/20 0.44
FFAR4 Q5NUL3 1/20 0.44
HMOX1 P09601 1/20 0.44
PDE2A O00408 1/20 0.43
HPGD P15428 1/20 0.42
LTA4H P09960 1/20 0.42
EPHX2 P34913 1/20 0.42
LMNA P02545 2/20 0.42
HIF1A Q16665 2/20 0.42
PTGS1 P23219 1/20 0.42
SLC6A2 P23975 1/20 0.42
PTGS2 P35354 1/20 0.42
SLC6A3 Q01959 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1699268 0.84 MAOB (0.43) CYP1A2CYP2C19ALDH1A1CYP2C9TSHR
SCHEMBL1699357 0.74 PRMT5 (0.50) CYP1A2CYP2C19ALDH1A1CYP2C9TSHR
SCHEMBL9981622 0.72 NPC1 (0.58) ALDH1A1HPGDKMT2AMEN1KDM4C
SCHEMBL1699176 0.70 NPC1 (0.49) KMT2AMEN1KDM4CMAOBL3MBTL1
SCHEMBL9982135 0.67 NPC1 (0.50) CYP1A2CYP2C19LMNAHIF1APTGS1
SCHEMBL3421201 0.67 LMNA (0.85) CYP1A2CYP2C19ALDH1A1FFAR1FFAR4
SCHEMBL29192686 0.65 MAOB (0.76) LMNAKMT2AMEN1MAOBL3MBTL1
SCHEMBL19586360 0.65 MAOB (0.77) CYP1A2ALDH1A1CYP2C9HPGDLMNA
SCHEMBL891345 0.65 MAOB (0.56) CYP1A2ALDH1A1CYP2C9HPGDLTA4H
SCHEMBL6211695 0.65 MAOB (0.55) CYP1A2ALDH1A1TSHRCYP2D6HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011163355-A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-12-29 WO disclosed