Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215156 | 0.94 | L3MBTL1 (0.52) | L3MBTL1EZH2KMT2AMEN1CCNA2 | |
| SCHEMBL954758 | 0.79 | CDK2 (0.64) | L3MBTL1CCNA2CDK2CDK1CCNB1 | |
| SCHEMBL16995307 | 0.78 | HTR4 (0.45) | L3MBTL1CCNA2CDK2CDK1CCNB1 | |
| SCHEMBL4288778 | 0.78 | CDK2 (0.61) | L3MBTL1KMT2AMEN1CCNA2CDK2 | |
| SCHEMBL8261124 | 0.78 | CDK2 (0.52) | L3MBTL1KMT2AMEN1CCNA2CDK2 | |
| SCHEMBL1286713 | 0.77 | CDK2 (0.63) | KMT2ACCNA2CDK2CDK1CCNB1 | |
| SCHEMBL8219320 | 0.77 | CDK2 (0.57) | CCNA2CDK2CDK1CCNB1CCNA1 | |
| SCHEMBL13934374 | 0.77 | CDK2 (0.57) | CCNA2CDK2CDK1CCNB1CCNA1 | |
| SCHEMBL8214922 | 0.77 | CDK2 (0.64) | L3MBTL1KMT2AMEN1CCNA2CDK2 | |
| SCHEMBL16995312 | 0.76 | L3MBTL1 (0.54) | L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845973-B1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LTD (GB) | 2015-08-12 | — | — | EP | disclosed |