Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 3/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16996951 | 0.88 | GNAI3 (0.40) | GNAI3GNAO1GNAI1 | |
| SCHEMBL25579776 | 0.87 | CHRNB2 (0.38) | HRH2HRH1HRH3CHRNB2CHRNB4 | |
| SCHEMBL24784856 | 0.79 | GNAO1 (0.50) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL8369959 | 0.77 | CHRNB2 (0.37) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL29314332 | 0.77 | HRH3 (0.33) | HRH3 | |
| SCHEMBL19545302 | 0.75 | CHRNB2 (0.32) | GNAI3GNAO1GNAI1CHRNB2CHRNB4 | |
| SCHEMBL25681871 | 0.74 | CHRNB2 (0.35) | GNAI3GNAO1GNAI1CHRNB2CHRNB4 | |
| SCHEMBL26675168 | 0.74 | CHRNB2 (0.35) | GNAI3GNAO1GNAI1CHRNB2CHRNB4 | |
| SCHEMBL1991711 | 0.74 | CHRNB2 (0.35) | GNAI3GNAO1GNAI1CHRNB2CHRNB4 | |
| SCHEMBL12209130 | 0.73 | CHRNB2 (0.32) | HRH3CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015120049-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS | PRINCIPIA BIOPHARMA, INC. (US) | 2015-08-13 | — | — | WO | disclosed |