Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.65 |
| ▸ | GRM8 | O00222 | 2/20 | 0.65 |
| ▸ | GRM6 | O15303 | 2/20 | 0.65 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.65 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.65 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.65 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.65 |
| ▸ | GRM5 | P41594 | 1/20 | 0.65 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.65 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.65 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.65 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.65 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.65 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.65 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.65 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.65 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.65 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169987 | 1.00 | GSR (0.65) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL6138602 | 0.87 | GRM8 (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL148726 | 0.87 | GRM8 (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL148727 | 0.87 | GRM8 (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL261316 | 0.86 | GSR (0.56) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL3870750 | 0.86 | GSR (0.56) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL290779 | 0.84 | GSR (0.59) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL457312 | 0.83 | GRM8 (0.69) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL457311 | 0.83 | GRM8 (0.69) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL1614707 | 0.83 | KMT2A (0.67) | GSRGRM8GRM6GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170240867-A1 | VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE VKORC1, A THERAPEUTIC TARGET OF COUMARIN AND THEIR DERIVATIVES | Baxalta GmbH (CH) | 2017-08-24 | — | — | US | claimed |
| EP-2292748-B1 | Method for producing gamma-carboxylated proteins | MEDLMMUNE LTD (GB) | 2014-12-17 | — | — | EP | claimed |
| EP-2272951-B1 | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives | BAXTER INT (US) | 2014-07-23 | — | — | EP | claimed |
| US-20130318640-A1 | VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE VKORC1, A THERAPEUTIC TARGET OF COUMARIN AND THEIR DERIVATIVES | BAXTER INTERNATIONAL INC. (US) | 2013-11-28 | — | — | US | claimed |
| EP-2189523-B1 | Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives | BAXTER INT (US) | 2012-01-04 | — | — | EP | claimed |
| JP-4777251-B2 | — | — | 2011-09-21 | — | — | JP | claimed |
| US-20110154520-A1 | Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives | BAXTER INTERNATIONAL INC. (US) | 2011-06-23 | — | — | US | claimed |
| EP-2272951-A1 | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives | Baxter International Inc (US) | 2011-01-12 | — | — | EP | claimed |
| EP-2189523-A1 | Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives | Baxter International Inc. (US) | 2010-05-26 | — | — | EP | claimed |
| EP-1673450-B1 | VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE VKORC1, A THERAPEUTIC TARGET OF COUMARIN AND THEIR DERIVATIVES | BAXTER INT (US) | 2010-04-28 | — | — | EP | claimed |
| EP-1325127-B1 | METHOD FOR THE PRODUCTION OF VITAMIN K-DEPENDENT PROTEINS | NOVO NORDISK HEALTHCARE AG (CH) | 2009-03-11 | — | — | EP | claimed |
| JP-2007512002-A | — | — | 2007-05-17 | — | — | JP | claimed |
| EP-1673450-A1 | VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE VKORC1, A THERAPEUTIC TARGET OF COUMARIN AND THEIR DERIVATIVES | BAXTER INTERNATIONAL INC. (US) | 2006-06-28 | — | — | EP | claimed |
| US-20050271644-A1 | Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives | BAXTER INTERNATIONAL INC. | 2005-12-08 | — | — | US | claimed |
| WO-2005040367-A1 | VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE VKORC1, A THERAPEUTIC TARGET OF COUMARIN AND THEIR DERIVATIVES | BAXTER INTERNATIONAL INC. (US) | 2005-05-06 | — | — | WO | claimed |
| US-20240151726-A1 | DIAGNOSTIC METHODS FOR LIVER DISORDERS | MESO SCALE TECHNOLOGIES, LLC. (US) | 2024-05-09 | — | — | US | disclosed |
| CN-109207462-B | Abnormal prothrombin, preparation method thereof, detection agent containing abnormal prothrombin, kit and application | 深圳市新产业生物医学工程股份有限公司 | 2021-05-11 | — | — | CN | disclosed |
| EP-1235569-A2 | MEDICAMENT AND COMBINATION OF COMPATIBLE MEDICAMENTS | responsif GmbH (DE) | 2002-09-04 | — | — | EP | disclosed |
| US-20020025983-A1 | Vitamin K and essential fatty acids | PABAY INVESTMENTS LIMITED (GB) | 2002-02-28 | — | — | US | disclosed |
| WO-2001037818-A2 | MEDICAMENT AND COMBINATION OF COMPATIBLE MEDICAMENTS | november Aktiengesellschaft Gesellschaft für Molekulare Medizin (DE) | 2001-05-31 | — | — | WO | disclosed |