SCHEMBL16999846

SCHEMBL16999846

O=C(NC(Cc1ccc(O)cc1)C(=O)Nc1ccccc1N1CCCCC1)c1cccs1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.65
NPSR1 Q6W5P4 4/20 0.65
LMNA P02545 3/20 0.65
TSHR P16473 2/20 0.65
MAPK1 P28482 1/20 0.65
ALDH1A1 P00352 6/20 0.58
HTT P42858 2/20 0.58
GAA P10253 1/20 0.57
HSPA1A P0DMV8 1/20 0.50
HSPA5 P11021 1/20 0.50
HSPA9 P38646 1/20 0.50
HSPA2 P54652 1/20 0.50
KDM4E B2RXH2 2/20 0.49
USP30 Q70CQ3 1/20 0.48
CTSL P07711 1/20 0.48
ALOX12 P18054 2/20 0.47
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C9 P11712 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18261138 0.93 MAPT (0.65) MAPTNPSR1LMNATSHRMAPK1
SCHEMBL16999327 0.93 MAPT (0.65) MAPTNPSR1LMNATSHRMAPK1
SCHEMBL16993870 0.91 ALDH1A1 (0.60) MAPTNPSR1LMNATSHRMAPK1
SCHEMBL16993938 0.91 MAPT (0.52) MAPTNPSR1LMNATSHRMAPK1
SCHEMBL16993927 0.85 HSPA1A (0.55) MAPTNPSR1LMNATSHRMAPK1
SCHEMBL16999273 0.82 CTSL (0.55) MAPTNPSR1TSHRALDH1A1GAA
SCHEMBL18261137 0.82 CTSL (0.55) MAPTNPSR1TSHRALDH1A1GAA
SCHEMBL24862991 0.81 MAPT (0.57) MAPTNPSR1LMNATSHRMAPK1
SCHEMBL19977040 0.81 MAPT (0.71) MAPTNPSR1LMNATSHRMAPK1
SCHEMBL16999323 0.80 ALDH1A1 (0.54) MAPTNPSR1LMNATSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3102193-B1 ANTIBACTERIAL AGENTS: N(ALPHA)-AROYL-N-ARYL-PHENYLALANINAMIDES UNIV RUTGERS (US) 2023-01-11 EP disclosed
WO-2015120320-A1 ANTIBACTERIAL AGENTS: N(ALPHA)-AROYL-N-ARYL-PHENYLALANINAMIDES RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2015-08-13 WO disclosed