Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.43 |
| ▸ | TUBB | P07437 | 3/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6113045 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL31673942 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL3967795 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL3088172 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL31674081 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL7998453 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL7117998 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL23857698 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL18018614 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1HPGDTUBB4ATUBB | |
| SCHEMBL20234384 | 0.75 | BRD4 (0.41) | KDM4EALDH1A1HPGDTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | ACHE, BCHE, HNMT | KDM4E 893/4885ALDH1A1 324/4885HPGD 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.